The increased rhabdomyolysis risk from grapefruit juice consumption due to the increased effective statin dose is minimal compared with the greater effect in preventing heart disease. Thus, for statins like simvastatin and lovastatin, with a relatively short half-life, taking grapefruit juice just in the evening produces about half the effect. Keywords: Grapefruit juice, drug interaction, statins, CYP3A4 P. If the juice is taken 12 hours before these statins, the reductions are, respectively, 43% and 66%, and for atorvastatin, 42% and 66%. Therefore, patients using statins are generally advised to avoid grapefruit juice consumption. When simvastatin or lovastatin are taken at the same time as grapefruit juice, the estimated reduction in LDL cholesterol is 48%, and in heart disease is 70%. Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with an LDL cholesterol of 4.8 mmol/L by 37%, reducing ischemic heart disease risk by 61%. Statins are the mainstay of cholesterol management but are not free. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Many people are prescribed drugs from the statin family to prevent heart attacks and strokes. Do not take Atorvastatin with grapefruit juice. We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. Notes for Consumers: Side effects from Atorvastatin may get worse if you drink grapefruit juice.
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